Agar and agarose used for Staphylococcus aureus biofilm cultivation impact fluoroquinolone tolerance.

ABSTRACT:

Aims

Staphylococcus aureus is an opportunistic pathogen whose treatment is further complicated by its ability to form biofilms. In this study, we examine the impact of growing S. aureus biofilms on different polymerizing surfaces, specifically agar and agarose, on the pathogen's tolerance to fluoroquinolones.

Methods and results

Biofilms of two methicillin-resistant strains of S. aureus were grown on agar or agarose in the presence of the same added nutrients, and their antibiotic susceptibility to two fluoroquinolones, moxifloxacin (MXF) and delafloxacin (DLX), were measured. We also compared the metabolism and extracellular polymeric substances (EPS) production of biofilms that were grown on agar and agarose.

Conclusions

Biofilms that were grown on agarose were cons

SUBMITTER: Power AD 

PROVIDER: S-EPMC11301810 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature