Supramolecular architectures in multicomponent crystals of imidazole-based drugs and trithiocyanuric acid.

ABSTRACT: The structures of three multicomponent crystals formed with imidazole-based drugs, namely metronidazole, ketoconazole and miconazole, in conjunction with trithiocyanuric acid are characterized. Each of the obtained adducts represents a different category of crystalline molecular forms: a cocrystal, a salt and a cocrystal of salt. The structural analysis revealed that in all cases, the N-H...N hydrogen bond is responsible for the formation of acid-base pairs, regardless of whether proton transfer occurs or not, and these molecular pairs are combined to form unique supramolecular motifs by centrosymmetric N-H...S interactions between acid molecules. The complex intermolecular forces acting in characteristic patterns are discussed from the geometric and energetic perspectives, involving Hirsh

SUBMITTER: Ben A 

PROVIDER: S-EPMC11301895 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature