Identification and validation of inflammatory subtypes in intrahepatic cholangiocellular carcinoma.

ABSTRACT:

Background

Inflammation plays a critical role in tumor development. Inflammatory cell infiltration and inflammatory mediator synthesis cause changes in the tumor microenvironment (TME) in several cancers, especially in intrahepatic cholangiocellular carcinoma (ICC). However, methods to ascertain the inflammatory state of patients using reliable biomarkers are still being explored.

Method

We retrieved the RNA sequencing and somatic mutation analyses results and the clinical characteristics of 244 patients with ICC from published studies. We performed consensus clustering to identify the molecular subtypes associated with inflammation. We compared the prognostic patterns, clinical characteristics, somatic mutation profiles, and immune cell infiltration patterns across inflamma

SUBMITTER: Gao B 

PROVIDER: S-EPMC11302004 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature