Gene regulatory networks reveal sex difference in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) has been observed to have significant sex differences in incidence, prognosis, and response to therapy. However, the molecular mechanisms responsible for these disparities have not been investigated extensively.

Methods

Sample-specific gene regulatory network methods were used to analyze RNA sequencing data from non-cancerous human lung samples from The Genotype Tissue Expression Project (GTEx) and lung adenocarcinoma primary tumor samples from The Cancer Genome Atlas (TCGA); results were validated on independent data.

Results

We found that genes associated with key biological pathways including cell proliferation, immune response and drug metabolism are differentially regulated between males and females in both healthy lung tissu

SUBMITTER: Saha E 

PROVIDER: S-EPMC11302009 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature