Hypoxia exacerbates the malignant transformation of gastric epithelial cells induced by long-term H. pylori infection.

ABSTRACT: Helicobacter pylori is a microaerophilic Gram-negative bacterium that resides in the human stomach and is classified as a class I carcinogen for gastric cancer. Numerous studies have demonstrated that H. pylori infection plays a role in regulating the function of host cells, thereby contributing to the malignant transformation of these cells. However, H. pylori infection is a chronic process, and short-term cellular experiments may not provide a comprehensive understanding of the in vivo situation, especially when considering the lower oxygen levels in the human stomach. In this study, we aimed to investigate the mechanisms underlying gastric cell dysfunction after prolonged exposure to H. pylori under hypoxic conditions. We conducted a co-culture experim

SUBMITTER: He Y 

PROVIDER: S-EPMC11302036 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature