Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy.

ABSTRACT: Mycobacterium tuberculosis (Mtb) as well as nontuberculous mycobacteria are intracellular pathogens whose treatment is extensive and increasingly impaired due to the rise of mycobacterial drug resistance. The loss of antibiotic efficacy has raised interest in the identification of host-directed therapeutics (HDT) to develop novel treatment strategies for mycobacterial infections. In this study, we identified amiodarone as a potential HDT candidate that inhibited both intracellular Mtb and Mycobacterium avium in primary human macrophages without directly impairing bacterial growth, thereby confirming that amiodarone acts in a host-mediated manner. Moreover, amiodarone induced the formation of (auto)phagosomes and enhanced autophagic targeting of mycobacteria in m

SUBMITTER: Kilinc G 

PROVIDER: S-EPMC11302041 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature