Rescue of pyrimidine-defective Pseudomonas aeruginosa through metabolic complementation.

ABSTRACT: Chronic infections harbor multiple pathogens where dynamic interactions between members of the polymicrobial community play a major role in determining the infection outcome. For example, in a nutrient-rich polymicrobial infection, bacteria have the potential to undergo evolutionary changes that impair their ability to synthesize essential metabolites. This adaptation may facilitate metabolic interdependencies between neighboring pathogens and lead to difficult-to-treat chronic infections. Our research group previously demonstrated that Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA), typically considered classical competitors, can adopt a cooperative lifestyle through bi-directional purine exchange medicated by exogenous DNA (eDNA) release. To further validate our

SUBMITTER: Mahmud HA 

PROVIDER: S-EPMC11302043 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature