FLT4 gene polymorphisms influence isolated ventricular septal defect predisposition in a Southwest China population.

ABSTRACT:

Background

Ventricular septal defect (VSD) is the most common congenital heart disease. Although a small number of genes associated with VSD have been found, the genetic factors of VSD remain unclear. In this study, we evaluated the association of 10 candidate single nucleotide polymorphisms (SNPs) with isolated VSD in a population from Southwest China.

Methods

Based on the results of 34 congenital heart disease whole-exome sequencing and 1000 Genomes databases, 10 candidate SNPs were selected. A total of 618 samples were collected from the population of Southwest China, including 285 VSD samples and 333 normal samples. Ten SNPs in the case group and the control group were identified by SNaPshot genotyping. The chi-square (χ²) test was used to evaluate the relatio

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11302092 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature