A panel of genotypically and phenotypically diverse clinical Acinetobacter baumannii strains for novel antibiotic development.

ABSTRACT: Acinetobacter baumannii is one of the most important pathogens worldwide. The intrinsic and acquired resistance of A. baumannii, coupled with the slow pace of novel antimicrobial drug development, poses an unprecedented and enormous challenge to clinical anti-infective therapy of A. baumannii. Recent studies in the field of pathogenicity, antibiotic resistance, and biofilms of A. baumannii have focused on the model strains, including ATCC 17978, ATCC 19606, and AB5075. However, these model strains represent only a limited portion of the heterogeneity in A. baumannii. Furthermore, variants of these model strains have emerged that show significant diversity not only at the genotypic level but also reflected in differences at the phenotypic levels of capsule

SUBMITTER: Sun C 

PROVIDER: S-EPMC11302250 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature