Relevance of the bacteriophage adherence to mucus model for Pseudomonas aeruginosa phages.

ABSTRACT: Pseudomonas aeruginosa infections are getting increasingly serious as antimicrobial resistance spreads. Phage therapy may be a solution to the problem, especially if improved by current advances on phage-host studies. As a mucosal pathogen, we hypothesize that P. aeruginosa and its phages are linked to the bacteriophage adherence to mucus (BAM) model. This means that phage-host interactions could be influenced by mucin presence, impacting the success of phage infections on the P. aeruginosa host and consequently leading to the protection of the metazoan host. By using a group of four different phages, we tested three important phenotypes associated with the BAM model: phage binding to mucin, phage growth in mucin-exposed hosts, and the influence of mucin on CRISPR immu

SUBMITTER: Almeida GMdF 

PROVIDER: S-EPMC11302309 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature