Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability.

ABSTRACT: Clouding of the eye lens or cataract is an age-related anomaly that affects middle-aged humans. Exploration of the etiology points to a great extent to oxidative stress due to different forms of reactive oxygen species/metabolites such as Hydrogen peroxide (H₂O₂) that are generated due to intracellular metabolism and environmental factors like radiation. If accumulated and left unchecked, the imbalance between the production and degradation of H₂O₂ in the lens could lead to cataracts. Our objective was to explore ex vivo the effects of H₂O₂ on lens physiology. We investigated transparency, intracellular pH (pH_i), intercellular gap junction coupling (GJC), hydrostatic pressure (HP) and membrane water permeability a

SUBMITTER: Varadaraj K 

PROVIDER: S-EPMC11302404 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature