Comparison of the Areas Under the Curve of Vancomycin Continuous vs. Intermittent Infusion in Critically Ill Pediatrics: A Randomized Clinical Trial.

ABSTRACT:

Background

Providing data on the superior efficacy of vancomycin administered based on the area under the curve over 24 hours to the minimum inhibitory concentration of vancomycin (AUC₂₄/MIC) is crucial. However, data on dosing and monitoring of vancomycin pharmacokinetics in the pediatric population are limited. Previous findings have showed that intermittent infusion of vancomycin (IIV) may not achieve the desired levels, continous infusions of vancomycin (CIV) reach the desired serum concentration faster than IIV and are associated with reduced nephrotoxicity.

Objectives

This study aimed to compare the serum concentrations, AUC₂₄, clinical variables, and adverse effects of two vancomycin administration methods in the pediatric population.

Methods<

SUBMITTER: Roshan N S B 

PROVIDER: S-EPMC11302439 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature