A case report of reversible left ventricular dysfunction due to azathioprine hypersensitivity syndrome.

ABSTRACT:

Background

Hypersensitivity reaction is a rare side effect during immunosuppressive treatment with azathioprine (AZA). Some cases of cardiac involvement have already been reported but causality is notoriously difficult to prove.

Case summary

We present the case of a 68-year-old man with two episodes of reversible left ventricular (LV) dysfunction. One month after treatment initiation with AZA, he developed non-specific symptoms, including mild chest pain. In the context of elevated cardiac biomarkers and markers of inflammation, echocardiography showed depressed systolic LV function. Biventricular dysfunction was shown on cardiac magnetic resonance imaging (CMR), but neither myocardial oedema nor late gadolinium enhancement was documented. There was full recovery of LV funct

SUBMITTER: Luscher D 

PROVIDER: S-EPMC11302448 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature