Association between preoperative proton pump inhibitor use and postoperative acute kidney injury in patients undergoing major surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) is a severe postoperative complication in patients undergoing major surgery. Proton pump inhibitors (PPIs) are used preoperatively as prophylaxis for postoperative gastrointestinal bleeding. Whether preoperative PPI use is associated with an increased risk of postoperative AKI remains uncertain.

Methods

This retrospective cohort study used electronic medical records from the clinical data warehouse of Peking University First Hospital to screen all adult hospitalizations undergoing major surgery between 1 January 2018 and 31 December 2020. Exposure was preoperative PPI use, defined as PPI use within 7 days before major surgery. The primary outcome was postoperative AKI, defined as AKI occurring within 7 days after major surgery; secondary

SUBMITTER: Zheng X 

PROVIDER: S-EPMC11302470 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature