Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.

ABSTRACT:

Background

The piriform cortex has been implicated in the initiation, spread and termination of epileptic seizures. This understanding has extended to surgical management of epilepsy, where it has been shown that resection or ablation of the piriform cortex can result in better outcomes. How and why the piriform cortex may play such a crucial role in seizure networks is not well understood. To answer these questions, we investigated the functional and structural connectivity of the piriform cortex in both healthy controls and temporal lobe epilepsy (TLE) patients.

Methods

We studied a retrospective cohort of 55 drug-resistant unilateral TLE patients and 26 healthy controls who received structural and functional neuroimaging. Using seed-to-voxel connectivity we compared the n

SUBMITTER: Lucas A 

PROVIDER: S-EPMC11302608 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature