Clostridium sporogenes increases fat accumulation in mice by enhancing energy absorption and adipogenesis.

ABSTRACT: Gut bacteria belonging to the Clostridium family play a pivotal role in regulating host energy balance and metabolic homeostasis. As a commensal bacterium, Clostridium sporogenes has been implicated in modulating host energy homeostasis, albeit the underlying mechanism remains elusive. Therefore, this study aimed to investigate the impact of C. sporogenes supplementation on various physiological parameters, intestinal morphology, particularly adipose tissue accumulation, and glucolipid metabolism in mice. The findings reveal that mice supplemented with C. sporogenes for 6 weeks exhibited a notable increase in body weight, fat mass, adipocyte size, and serum triglyceride (TG) levels. Notably, the increased fat accumulation is observed despite consistent feed inta

SUBMITTER: Du L 

PROVIDER: S-EPMC11302664 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature