Intradermal infection and dissemination of Candida auris in immunocompetent and immunocompromised mouse models.

ABSTRACT: Candida auris, an emerging fungal pathogen, predominately colonizes human skin leading to serious invasive infections in humans. Though it is assumed that skin colonization can lead to invasive infection, dissemination potential of C. auris from skin to internal organs is still unknown. In this study, immunocompetent and immunocompromised mouse models of intradermal skin infection were used to compare the dissemination potential of C. auris to internal organs. Our results suggest that C. auris persists in the skin tissue of both immunocompetent and immunocompromised infected mice even at 30 days post-infection. Furthermore, C. auris can readily disseminate from skin tissue to internal organs such as the spleen and kidney as early as 24 h post-infection an

SUBMITTER: Towns KA 

PROVIDER: S-EPMC11302725 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature