Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.

ABSTRACT: Tumor endothelial marker 1 (TEM1), an activated mesenchymal cell marker, is implicated in tissue remodeling and repair. Herein, we investigated the role and therapeutic implications of TEM1 in abdominal aortic aneurysm (AAA), a potentially life-threatening aortic disease characterized by vascular inflammation and matrix turnover. Characterization of human AAA revealed increased TEM1 expression derived mainly from medial vascular smooth muscle cells (VSMCs) and adventitial fibroblasts. Bioinformatics analysis demonstrated the association between TEM1-expressing VSMCs and fibroblasts and collagen gene expression. Consistently, collagen content and TEM1 expressed by VSMCs and fibroblasts were increased during CaCl₂-induced AAA formation in mice. TEM1 silencing in VSMCs and f

SUBMITTER: Hong YK 

PROVIDER: S-EPMC11302889 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature