Gut microbial composition is altered in sarcopenia: A systematic review and meta-analysis of clinical studies.

ABSTRACT: Increasing evidence has shown that gut microbiota (GM) was involved in the pathophysiology of musculoskeletal disorders through multiple pathways such as protein anabolism, chronic inflammation and immunity, and imbalanced metabolism. We performed a systematic review and meta-analysis of human studies to evaluate GM diversity differences between individuals with and without sarcopenia, and explore bacteria with potential to become biomarkers. PubMed, Embase and Cochrane library were systematically searched from inception to February 16, 2024. Studies were included if they (1) sampled adults with sarcopenia, and (2) performed GM analysis and reported α-diversity, β-diversity or relative abundance. The methodological quality of included studies and the certainty of evidence were assessed thr

SUBMITTER: Mai X 

PROVIDER: S-EPMC11302912 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature