Single and Combined Serum Proteins Expressed in TB Infection are Candidates for Point-of-care Diagnostic Testing of Active TB Patients in Lambarene, Gabon.

ABSTRACT:

Background and objectives

Point-of-care testing using nonsputum samples like serum or plasma proteins can improve tuberculosis (TB) patients access to a definitive diagnosis, especially in resource-constrained and remote areas. Recently, approximately 400 proteins were identified as playing a role in the pathogenesis of TB, offering a translational clinical research repository for TB. In a previous manuscript, we proved the potential use of these proteins for point-of-care testing for active TB diagnosis. The present work aims to confirm the performance of single and combination proteins to select the best candidate biomarkers for further development as a diagnostic testing tool for active TB.

Methods

Seventy-four participants were assessed on the diagnostic performance of 1

SUBMITTER: Essone PN 

PROVIDER: S-EPMC11303003 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature