Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.

ABSTRACT: Sensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Although decades of work have established that these dynamics are mediated by rapid fluctuations in sensory cortical activity, we have a limited understanding of the brain regions and pathways that orchestrate these changes. Neurons in the orbitofrontal cortex (OFC) encode contextual information, and recent data suggest that some of these signals are transmitted to sensory cortices. Whether and how these signals shape sensory encoding and perceptual sensitivity remain uncertain. Here, we asked whether the OFC mediates context-dependent changes in auditory cortical sensitivity and sound perception by monitoring and manipulating OFC activity in freely moving Mongolian gerbils of both sexe

SUBMITTER: Macedo-Lima M 

PROVIDER: S-EPMC11303099 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature