Causal associations between sleep traits and temporomandibular disorders: a bidirectional mendelian randomization analysis.

ABSTRACT:

Objectives

This study aims to investigate the relationship between five sleep traits (insomnia, sleep duration, getting up in morning, snoring, and daytime nap) and temporomandibular disorders (TMD) using bi-directional Mendelian randomization.

Methods

The bi-directional Mendelian randomization study was conducted in two stages. Initially, sleep traits were examined as exposures while TMD was evaluated as an outcome, whereas the second step was reversed. The inverse variance weighted (IVW) method and other Mendelian randomization methods were used for analysis. Furthermore, we performed the MR-Egger intercept, MR-PRESSO, Cochran's Q test, and "Leave-one-out" to assess the levels of pleiotropy and heterogeneity.

Results

The IVW method indicates that getting up in the m

SUBMITTER: Xu L 

PROVIDER: S-EPMC11303139 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature