Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8⁺ T lymphocytes.

ABSTRACT:

Introduction

CD8⁺ cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide-MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognate interaction promotes the organisation of intimate cell-cell connections that involve cytoskeleton rearrangement to enable effector function and clearance of the target cell. This is key for the asymmetric transport and mobilisation of lytic granules to the cell-cell contact, promoting directed secretion of lytic mediators such as granzymes and perforin. Mitochondria play a role in regulating CTL function by controlling processes such as calcium flux, providing the necessary energy through oxidative phosphorylation, and its o

SUBMITTER: Gomez-Moron A 

PROVIDER: S-EPMC11303187 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature