Evidence of a causal relationship between blood pressure and pathological scars: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Recent advancements in basic medicine and epidemiology suggest a potential influence of blood pressure on scar formation, yet the specifics of this relationship are not fully understood. This study aims to clarify the causal link between blood pressure and the development of pathological scars using Mendelian randomization (MR).

Methods

This study employed genetic variants closely linked to blood pressure as instrumental variables to explore the relationship between blood pressure and pathological scars. The inverse variance weighted (IVW) method was used for analysis.

Results

Our analysis identified a notable association where higher blood pressure was correlated with a lower risk of pathological scars. Specifically, an increase in diastolic blood pressure

SUBMITTER: Du D 

PROVIDER: S-EPMC11303301 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature