Untargeted metabolomics reveals the mechanism of amantadine toxicity on Laminaria japonica.

ABSTRACT: The antiviral agent amantadine is frequently detected in seawater and marine organisms. Because of increasing concentrations, amantadine has become a contaminant of emerging concern. This compound has toxic effects on the brown algae Laminaria japonica. The effects of amantadine on the biological processes of L. japonica and the corresponding toxic mechanisms remain unclear. In this study, amantadine toxicity on L. japonica was investigated using histopathological and physiological characteristics combined with metabolomics analysis. Changes in metabolites were determined by untargeted metabolomics after exposure to 10⁷ ng/L amantadine for 72 h. The catalase activity in the exposure group slightly increased, whereas the superoxide dismutase activity greatly

SUBMITTER: Wang X 

PROVIDER: S-EPMC11303324 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature