Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A_2A and A_2B receptors.

ABSTRACT: Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling. We investigated whether altered AR expression contributes to the development of fibrotic diseases and whether A_2AAR and A_2BAR upregulation inhibits fibrotic responses. Primary human lung fibroblasts (HLFs) from normal (NHLFs) or patients with idiopathic pulmonary fibrosis (DHLF) were used for in vitro testing. Murine models of fibrotic liver or pulmonary disease were developed by injecting thioacetamide intraperitoneally, by feeding a high-fat diet, or by intratracheal instillation of bleomycin. Modafinil, which activates cAMP signaling via A_2AAR and A_2BAR, was administered orally. The protein amounts of A_2AAR, A<

SUBMITTER: Li H 

PROVIDER: S-EPMC11303359 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature