Primary tumor resection for asymptomatic colorectal cancer patients with synchronous unresectable metastases: a meta-analysis of randomized controlled trials and case-matched studies.

ABSTRACT:

Purpose

The value of upfront primary tumor resection (PTR) for asymptomatic unresectable metastatic colorectal cancer (mCRC) patients remains contentious. This meta-analysis aimed to assess the prognostic significance of upfront PTR for asymptomatic unresectable mCRC.

Methods

A systematic literature search was performed on June 21st, 2024. To minimize the bias and ensure robust evidence, only randomized controlled trials (RCTs) and case-matched studies (CMS) that compared PTR followed by chemotherapy to chemotherapy alone were included. The primary outcome was overall survival (OS), while cancer-specific survival (CSS) served as the secondary outcome.

Results

Eight studies (three RCTs and five CMS) involving 1221 patients were included. Compared to chemotherapy alone,

SUBMITTER: Huang J 

PROVIDER: S-EPMC11303460 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature