Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers.

ABSTRACT:

Purpose

Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight (BW). The present evaluation aimed to assess the influence of body mass-related covariates on rifampicin's pharmacokinetics (PK) parameters in more detail using non-linear mixed effects modeling (NLMEM).

Methods

Twenty-four healthy Caucasian volunteers were enrolled in a bioequivalence study, each receiving a test and a reference tablet of 600 mg of rifampicin separated by a wash-out period of at least 9 days. Monolix version 2023R1 was used for NLMEM. Monte Carlo simulations (MCS) were performed to visualize the relationship of body size descriptors to the exposure to rifampicin.

Results

A one-compartment model with nonl

SUBMITTER: Bilal M 

PROVIDER: S-EPMC11303472 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature