Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis.

ABSTRACT: Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this study was to combine sublingual video-microscopy, plasma proteomics and live cell imaging to uncover further pathways of eGC damage in patients with coronavirus disease 2019 (COVID-19) or bacterial sepsis. This secondary analysis of the prospective multicenter MICROCODE study included 22 patients with COVID-19 and 43 patients with bacterial sepsis admitted to intermediate or intensive care units and 10 healthy controls. Interleukin-6 (IL-6) was strongly associated with damaged eGC and correlated both with eGC dimensions (r_s=0.36, p

SUBMITTER: Drost CC 

PROVIDER: S-EPMC11303473 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature