Maintenance therapy for cytogenetically high-risk multiple myeloma: landscape in the era of novel drugs.

ABSTRACT: Although the significant strides in novel therapeutic approaches have prolonged the survival of multiple myeloma (MM) patients, the unfavorable prognosis of cytogenetically high-risk newly diagnosed MM (NDMM) remains intractable with the lack of consensus regarding the choice of maintenance regimens. Therefore, this study was initiated with the aim of examining the effectiveness of various maintenance treatments for this group of patients in jeopardy. Overall, 17 studies with 1937 high-risk NDMM patients were included in the network meta-analysis. Combination therapies involving novel drugs presented encouraging prospects in the maintenance phase, while the patients and circumstances for the application of different regimens still needed to be further distinguished and clarified. To invest

SUBMITTER: Gu X 

PROVIDER: S-EPMC11303491 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature