Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning.

ABSTRACT: Mammalian dentition exhibits distinct heterodonty, with more simple teeth located in the anterior area of the jaw and more complex teeth situated posteriorly. While some region-specific differences in signalling have been described previously, here we performed a comprehensive analysis of gene expression at the early stages of odontogenesis to obtain complete knowledge of the signalling pathways involved in early jaw patterning. Gene expression was analysed separately on anterior and posterior areas of the lower jaw at two early stages (E11.5 and E12.5) of odontogenesis. Gene expression profiling revealed distinct region-specific expression patterns in mouse mandibles, including several known BMP and FGF signalling members and we also identified several new molecules exhibiting significant

SUBMITTER: Nevorankova P 

PROVIDER: S-EPMC11303781 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature