Chemotherapy for post-menopausal women with early breast cancer seems not to result in clinically significant changes in thyroid function.

ABSTRACT:

Objective

Adjuvant chemotherapy is often indicated in patients diagnosed with early breast cancer (EBC). Among others, weight gain is one of the observed side effects of both chemotherapy and other cancer treatments; however, the mechanism is not well-described. In this study, we aimed to assess thyroid function before and shortly after the course of chemotherapy for EBC.

Methods

This is a prospective cohort study of women diagnosed with EBC. The main outcome was the thyroid function and body weight before and after completing chemotherapy. Secondary outcomes were the presence of thyroid autoantibodies and treatment radiation dosage. We included 72 patients treated with adjuvant chemotherapy, whereas 59 patients also received supraclavicular locoregional radiotherapy. Triple

SUBMITTER: Marina D 

PROVIDER: S-EPMC11303825 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature