Osteoarthritis, osteoarthritis treatment and risk of incident dementia: a prospective cohort study based on UK Biobank.

ABSTRACT:

Background

We aimed to investigate the association between OA and treatment with dementia risk and structural brain abnormalities.

Methods

We recruited a total of 466,460 individuals from the UK Biobank to investigate the impact of OA on the incidence of dementia. Among the total population, there were 63,081 participants diagnosed with OA. We subsequently categorised the OA patients into medication and surgery groups based on treatment routes. Cox regression models explored the associations between OA/OA treatment and dementia risk, with the results represented as hazard ratios (HRs) and 95% confidence intervals (95% CI). Linear regression models assessed the associations of OA/OA therapy with alterations in cortical structure.

Results

During an average of 11.90 (± 1

SUBMITTER: Guo R 

PROVIDER: S-EPMC11303829 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature