Study on the mechanism of hepatotoxicity of Aucklandiae radix through liver metabolomics and network pharmacology.

ABSTRACT:

Background

Aucklandiae Radix (CAR) and its roasted processed products (PAR) are extensively used in various Chinese patent medicines due to their diverse pharmacological activities. However, numerous side effects of CAR have been reported and the hepatotoxicity and the corresponding mechanisms have not been thoroughly investigated. Our study aims to explore the underlying mechanism of the hepatotoxic impacts of CAR.

Methods

In this study, metabolomic analysis was performed using liver tissue from the mice administered with different dosages of CAR/PAR extracts to examine the hepatotoxic impacts of CAR and elucidate the underlying mechanism. Network pharmacology was employed to predict the potential molecular targets and associated signaling pathways based on the distinctive

SUBMITTER: Song S 

PROVIDER: S-EPMC11303830 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature