Inflammatory biomarkers and state of the tibiofemoral joint in the osteoarthritic knee: a narrative review.

ABSTRACT:

Background

The healing process is initiated by injurious stimuli in response to cellular damage. Upon recruiting proinflammatory biomarkers to the tissue site of injury, the release of additional biomarkers occurs, including the likes of cytokines, matrix molecules, macrophages, neutrophils, and others. This influx of immune system mediators can occur for chronic periods, and though its intention is for healing the original injurious stimuli, it is also suspected of causing long term cartilage impairment following internal structure damage. The objective of this narrative review is to identify which inflammatory factors have the leading roles in the progression of osteoarthritis (OA) following knee injuries and how they fluctuate throughout the healing process, both acutely and chr

SUBMITTER: Kennedy MI 

PROVIDER: S-EPMC11304101 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature