Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.

ABSTRACT:

Importance

Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.

Objective

To determine whether acetaminophen increases days alive and free of organ dysfunction in sepsis compared with placebo.

Design, setting, and participants

Phase 2b randomized, double-blind, clinical trial conducted from October 2021 to April 2023 with 90-day follow-up. Adults with sepsis and respiratory or circulatory organ dysfunction were enrolled in the emergency department or intensive care unit of 40 US academic hospitals within 36 hours of presentation.

Intervention

Patients were randomized to 1 g of acetaminophen intravenously every 6 hours or pla

SUBMITTER: Ware LB 

PROVIDER: S-EPMC11304120 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature