Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.

ABSTRACT: Hippocampal CA1 neurons show intense firing at specific spatial locations, modulated by isolated landmarks. However, the impact of real-world scene transitions on neuronal activity remains unclear. Moreover, long-term neural recording during movement challenges device stability. Conventional rigid-based electrodes cause inflammatory responses, restricting recording durations. Inspired by the jellyfish tentacles, the multi-conductive layer ultra-flexible microelectrode arrays (MEAs) are developed. The tentacle MEAs ensure stable recordings during movement, thereby enabling the discovery of soft boundary neurons. The soft boundary neurons demonstrate high-frequency firing that aligns with the boundaries of scene transitions. Furthermore, the localization ability of soft boundary neurons impr

SUBMITTER: Lv S 

PROVIDER: S-EPMC11304256 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature