Region-Specific CD16⁺ Neutrophils Promote Colorectal Cancer Progression by Inhibiting Natural Killer Cells.

ABSTRACT: The colon is the largest compartment of the immune system, with innate immune cells exposed to antigens in the environment. However, the mechanisms by which the innate immune system is instigated are poorly defined in colorectal cancer (CRC). Here, a population of CD16⁺ neutrophils that specifically accumulate in CRC tumor tissues by imaging mass cytometry (IMC), immune fluorescence, and flow cytometry, which demonstrated pro-tumor activity by disturbing natural killer (NK) cells are identified. It is found that these CD16⁺ neutrophils possess abnormal cholesterol accumulation due to activation of the CD16/TAK1/NF-κB axis, which upregulates scavenger receptors for cholesterol intake including CD36 and LRP1. Consequently, these region-specific CD16⁺ neutroph

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11304263 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature