Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation.

ABSTRACT: Minerals play a vital role, working synergistically with enzymes and other cofactors to regulate physiological functions including tissue healing and regeneration. The bioactive characteristics of mineral-based nanomaterials can be harnessed to facilitate in situ tissue regeneration by attracting endogenous progenitor and stem cells and subsequently directing tissue-specific differentiation. Here, cellular responses of human mesenchymal stem/stromal cells to traditional bioactive mineral-based nanomaterials, such as hydroxyapatite, whitlockite, silicon-dioxide, and the emerging synthetic 2D nanosilicates are investigated. Transcriptome sequencing is utilized to probe the cellular response and determine the significantly affected signaling pathways due to exposure to these inorganic nanomat

SUBMITTER: Murali A 

PROVIDER: S-EPMC11304299 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature