Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.

ABSTRACT:

Objectives

Endothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung function decline and worsening dyspnea.

Methods

A prospective cohort study comprising patients from the Copenhagen municipality. We included 698 PLWH with undetectable viral load. Biomarkers and demographics were measured at baseline, spirometry [forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC)] and dyspnea score both at baseline and 2-year follow-up.Both biomarkers were dichotomized at the 3rd quartile. Decline in lung function was estimated using a linear mixed model with patient-specific random eff

SUBMITTER: Ronn C 

PROVIDER: S-EPMC11304346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature