Translocation of Antimicrobial Peptides across Model Membranes: The Role of Peptide Chain Length.

ABSTRACT: Cushioned lipid bilayers are structures consisting of a lipid bilayer supported on a solid substrate with an intervening layer of soft material. They offer possibilities for studying the behavior and interactions of biological membranes more accurately under physiological conditions. In this work, we continue our studies of cushion formation induced by histatin 5 (²⁴Hst5), focusing on the effect of the length of the peptide chain. ²⁴Hst5 is a short, positively charged, intrinsically disordered saliva peptide, and here, both a shorter (¹⁴Hst5) and a longer (⁴⁸Hst5) peptide variant were evaluated. Experimental surface active techniques were combined with coarse-grained Monte Carlo simulations to obtain information about these peptides. Results show

SUBMITTER: Skog AE 

PROVIDER: S-EPMC11304388 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature