Circulating tumour DNA analysis for early detection of lung cancer: a systematic review.

ABSTRACT:

Background

Circulating tumor DNA (ctDNA) analysis has been applied in cancer diagnostics including lung cancer. Specifically for the early detection purpose, various modalities of ctDNA analysis have demonstrated their potentials. Such analyses have showed diverse performance across different studies.

Methods

We performed a systematic review of original studies published before 1 January 2023. Studies that evaluated ctDNA alone and in combination with other biomarkers for early detection of lung cancer were included.

Results

The systematic review analysis included 56 original studies that were aimed for early detection of lung cancer. There were 39 studies for lung cancer only and 17 for pan-cancer early detection. Cancer and control cases included were heterogenous a

SUBMITTER: Lam WKJ 

PROVIDER: S-EPMC11304429 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature