Potential role of short-chain fatty acids in the pathogenesis and management of acute lymphocytic leukemia.

ABSTRACT: Acute lymphocytic leukemia (ALL) is an aggressive hematological malignancy of highly proliferative lymphoblasts. ALL is the most common cancer in children, and is typically treated with combination chemotherapy. The 5-year survival of ALL improved significantly in recent decades with this treatment approach. However, certain age groups (below 2 and over 10 years of age) have much worse prognosis, and over 50% of patients with ALL experience long-term side effects proportional to the dosage of anticancer drugs. Therefore, different treatment strategies are required to improve survival in ALL and to reduce side effects of chemotherapy. Since epigenetic modifications are dominantly reversible, "epidrugs" (drugs targeting epigenetic markers) are considered for feasibility in the treatment of A

SUBMITTER: Song Y 

PROVIDER: S-EPMC11304434 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature