The Dimensionality of Hydrogen Bond Networks Induces Diverse Physical Properties of Peptide Crystals.

ABSTRACT: Short peptides are attractive building blocks for the fabrication of self-assembled materials with significant biological, chemical, and physical properties. The microscopic and macroscopic properties of assemblies are usually closely related to the dimensionality of formed hydrogen bond networks. Here, two completely different supramolecular architectures connected by distinct hydrogen bond networks were obtained by simply adding a hydroxyl group to switch from cyclo-tryptophan-alanine (cyclo-WA) to cyclo-tryptophan-serine (cyclo-WS). While hydroxyl-bearing cyclo-WS molecules provided an additional hydrogen bond donor that links to adjacent molecules, forming a rigid three-dimensional network, cyclo-WA arranged into a water-mediated zipper-like structure with a softer two-dimensional laye

SUBMITTER: Yuan H 

PROVIDER: S-EPMC11304472 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature