Discrepancies between general and central obesity in arterial stiffness: observational studies and Mendelian randomization study.

ABSTRACT:

Background

Obesity has been linked to arterial stiffness, while no consensus was reached on the association. We aimed to clarify the association of general and central obesity with arterial stiffness by combining observational studies and Mendelian randomization (MR) study.

Methods

Two cross-sectional studies were performed in UK Biobank and Fuqing Cohort, respectively. Two-sample MR study was conducted using summary data of GWASs from GIANT consortium and UK Biobank. General obesity and central obesity were measured using body mass index (BMI) and waist circumference (WC), respectively. Arterial stiffness was measured by arterial stiffness index (ASI) in UK Biobank or branchial-ankle pulse wave velocity (baPWV) in Fuqing Cohort.

Results

Two observational studies foun

SUBMITTER: Huang W 

PROVIDER: S-EPMC11304581 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature