The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.

ABSTRACT: Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression

SUBMITTER: Gong T 

PROVIDER: S-EPMC11304603 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature