Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.

ABSTRACT:

Background

Vitamin A is essential for physiological processes like vision and immunity. Vitamin A's effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationship between gut metagenome composition and six vitamin A-related metabolites (two retinoid: -retinol, 4 oxoretinoic acid (oxoRA) and four carotenoid metabolites, including beta-cryptoxanthin and three carotene diols).

Methods

We included 1053 individuals from the TwinsUK cohort with vitamin A-related metabolites measured in serum and faeces, diet history, and gut microbiome composition assessed by shotgun metagenome sequencing. Results were replicated in 327 women from the ZOE PREDICT-1 study.

Results

Five vitamin A-related ser

SUBMITTER: Valdes AM 

PROVIDER: S-EPMC11304618 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature