Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults.

ABSTRACT: Previous research on autism spectrum disorders (ASD) have showed important volumetric alterations in the cerebellum and brainstem. Most of these studies are however limited to case-control studies with small clinical samples and including mainly children or adolescents. Herein, we aimed to explore the association between the cumulative genetic load (polygenic risk score, PRS) for ASD and volumetric alterations in the cerebellum and brainstem, as well as global brain tissue volumes of the brain among adults at the population level. We utilized the latest genome-wide association study of ASD by the Psychiatric Genetics Consortium (18,381 cases, 27,969 controls) and constructed the ASD PRS in an independent cohort, the UK Biobank. Regression analyses controlled for multiple comparisons with t

SUBMITTER: Mohammad S 

PROVIDER: S-EPMC11304666 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature