Circulating inflammatory cytokines and the risk of sepsis: a bidirectional mendelian randomization analysis.

ABSTRACT:

Background

Sepsis is a life-threatening condition that is characterized by multiorgan dysfunction and caused by dysregulated cytokine networks, which are closely associated with sepsis progression and outcomes. However, currently available treatment strategies that target cytokines have failed. Thus, this study aimed to investigate the interplay between genetically predicted circulating concentrations of cytokines and the outcomes of sepsis and to identify potential targets for sepsis treatment.

Methods

Data related to 35 circulating cytokines in 31,112 individuals (including 11,643 patients with sepsis) were included in genome-wide association studies (GWASs) from the UK Biobank and FinnGen consortia. A bidirectional two-sample Mendelian randomization (MR) analysis was perf

SUBMITTER: Jiang WX 

PROVIDER: S-EPMC11304706 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature