Efficacy of ivermectin and its metabolites against Plasmodium falciparum liver stages in primary human hepatocytes.

ABSTRACT: Ivermectin, a broad-spectrum anti-parasitic drug, has been proposed as a novel vector control tool to reduce malaria transmission by mass drug administration. Ivermectin and some metabolites have mosquito-lethal effect, reducing Anopheles mosquito survival. Ivermectin inhibits liver stage development in a rodent malaria model, but no inhibition was observed in a primate malaria model or in a human malaria challenge trial. In the liver, cytochrome P450 3A4 and 3A5 enzymes metabolize ivermectin, which may impact drug efficacy. Thus, understanding ivermectin metabolism and assessing this impact on Plasmodium liver stage development is critical. Using primary human hepatocytes (PHHs), we characterized ivermectin metabolism and evaluated the efficacy of ivermectin and its primary

SUBMITTER: Annamalai Subramani P 

PROVIDER: S-EPMC11304735 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature